In Vitro and In Vivo Inhibitory Effects of Interferon α 2b on CML Granuloerythroid Precursors

Chronic myelogenous leukemia (CML) is a clonal hemopathy in which malignant transformation probably occurs in an early hemopoietic precursor cell. The initial chronic phase is easily treated by chemotherapy, but the fatal course of the disease rapidly evolves into the acute phase that is very difficult to control with conventional drugs.