Increased renal damage in hypocomplementemic patients with ANCA-associated vasculitis: retrospective cohort study

Introduction The complement system has an important role in the pathogenesis of vasculitis associated with antineutrophilic cytoplasmic antibody (AAV) mainly at the level of the kidneys because patients with complement deposits on the glomerular basal membrane present more aggressive disease compared with those with pauci-immune vasculitis.