Chromium(III) complexes of dimethyl diphenyldithiophosphates: Synthesis, characterization, and antibacterial studies

AbstractDimethyl diphenyldithiophosphate complexes of Cr(III), [{(ArO)2PS2}3Cr] [Ar = 2,4-(CH3)2C6H3 (1), 2,5-(CH3)2C6H3 (2), 3,4-(CH3)2C6H3 (3) and 3,5-(CH3)2C6H3 (4)], have been synthesized and structurally characterized by IR, heteronuclear NMR (1H, 13C and 31P) spectroscopic and single crystal X-ray analyses. The crystal structure of complex 4 reveals mononuclear units with the Cr(III) centre chelated in bidentate fashion by six S atoms of the three diphenyldithiophosphate ligands to form octahedral geometry. The main core of the system comprised of four membered (CrS2P)3 heteroatomic ring and Cr(III) centre. The ligands and complexes were evaluated for their antibacterial potential against six bacterial strains (K. pneumoniae, E.coli, P. aeruginosa, B. subtilis, S. aureus and S. typhimurium). The metal derivatives of chromium complexes were found to be more active against the bacterial strains as compared to the free ligands.