SENSIBILITY OF CLINICAL ISOLATES TO LEVOFLOXACIN UNDER THE CONDITIONS OF INCREASING ANTIMICROBIAL RESISTANCE

The appearance of comparatively new diseases, caused by multi-resistant microbial species and their toxins, as well as the increase in the population of patients at risk imposes the application of contemporary approach when choosing antimicrobial therapy. Suitable medicine which meets the modern needs of antimicrobial therapy is Levofloxacin. The purpose of this recent investigation is to determine the antimicrobial resistance of the most frequent clinical isolates to Levofloxacin. The resistance of 183 isolates of Gram (+) and Gram (-) bacteria ( S. aureus , S. pneumoniae , S. agalactiae , Enterococcus spp. , family Enterobacteriaceae , P. aeruginosa and Acinetobacter spp.) has been investigated , using DDM and BDM . One of the 25 investigated S. aureus strains has shown resistance to Levofloxacin ,while S. pneumoniae and S. agalactiae have not.The half of the tested Enterococcus spp. strains have been levofloxacin resistant. Among 119 investigated Gram (-) bacteria, 41 have shown resistance to Levofloxacin, (mainly due to Enterobacteriaceae, producing Extended Spectrum Beta Lactamases and multi –resistant Acinetibacter spp.)