Mitochondrial impairment in HIV-infected children

Purpose of the study Mechanisms of mitochondrial impairment induced by HIV infection itself and highly active antiretroviral therapy (HAART) are well-studied in adults. However, there is more left to know in children, since they are the first following-up generation with the disease. The aim of this study is to determine whether there are alterations in mtDNA content and MRC dysfunctions in peripheral blood mononuclear cells (PBMCs) in HAART-treated and non-HAART-treated HIV-infected children.