Correlations between cell-cycle perturbations and survival levels after exposure to adriamycin for two Chinese hamster cell lines☆

Abstract The cell-cycle perturbation and cell inactivation after adriamycin (ADR) exposure were measured in two Chinese hamster cell lines differing in ADR sensitivity. Based on DNA distribution analysis, it was found that the rate of G 1 fraction depletion following low-dose ADR treatment was related to the level of cell inactivation. The results indicate that gross cellular sensitivity to ADR can be predicted rapidly by this approach.