ОСОБЕННОСТИ РЕГУЛЯЦИИ МОТОРНОЙ АКТИВНОСТИ ТОЛСТОЙ КИШКИ ПРИ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЯХ КИШЕЧНИКА

Introduction. It is known that biologically active substances (serotonin, acetylcholine) participate in the regulation of motor activity of the intestine in patients with inflammatory bowel diseases (IBD). The aim of the study was to determine the concentration of neurotransmitters of acetylcholine and serotonin in the serum at IBD. Material and methods. 69 patients with IBD were examined. The control group consisted of 30 volunteers regularly undergoing a prophylactic check-up. The concentration of Ach and serotonin in serum was determined. Statistical processing of the results was carried out using a nonparametric analog of the variance analysis. Result and discussion. The concentration of 5-HT in the blood of patients with IBD: 0.39 ± 0.05 μg. So, it is established that the presence of the disease promotes an increase in the concentration of Ac and serotonin. There is a violation of the neuronal regulation of the functional activity of the digestive system as a vicious circle. In patients, in contrast to the control group, there is a high initial level of neurotransmitter concentration. Conclusion. In the chain of cause-effect relationships, the main link is identified, this is the level of concentration of neurotransmitters. Patients have a high quantitative composition of neurotransmitters. Perhaps the determination of the concentration of BAS will allow us to find the line between adaptation and disease.