Mechanism of accommodation in a sensitized human leukocyte antigen transgenic murine cardiac transplant model

Background Presence of donor specific antibodies (Abs) is detrimental to post transplant allograft function. Some sensitized recipients have successfully undergone transplantation following pretransplant conditioning regimen utilizing plasmapheresis and/or intravenous immunoglobulin therapy, but underlying mechanisms that confer such allograft protection are undefined.