Preparation method of oral high-density lipoprotein liposome

The invention provides a preparation method of oral high-density lipoprotein liposome. The oral high-density lipoprotein is prepared from the components (calculated according to 1000ml) of: 20-400 ml of high-density lipoprotein solution, 20-150g of sorbitol, 2-50g of beta-cyclodextrin, 2-50g of PEG (Polyethylene Glycol) (2000-8000), 2-15g of disodium hydrogen phosphate (12 H2O), 0.2-2g of disodium hydrogen phosphate (2 H2O), 2-60g of polyvinyl alcohol, 15-90g of soybean phospholipid, 2-20g of vitamin E, 0.5-20g of cholesterol and suitable amount of ethyl alcohol. The prepared oral high-density lipoprotein liposome has the characteristics that the oral high-density lipoprotein liposome can tolerate the conventional moist heat sterilization, can also keep the stability for more than 2-5 hours in the strong acid environment with a pH value smaller than 2 and is also insensitive to the attenuation treatment, and the stability of the oral high-density lipoprotein liposome is greatly improved compared with that of the conventional liposome.