Familial spinal neurofibromatosis: three generations of identical level symptomatic tumours

A 62-year-old man with neurofibromatosis type 1 presented with slowly progressive weakness in the right leg and impaired bladder function. Physical examination revealed bilateral brisk deep tendon reflexes and extensor plantar reflex. He had dozens of cafe au lait spots and cutaneous neurofibromas. His 12-year-old granddaughter presented with toe walking and weakness in the right hand. She showed several (>6) cafe au lait …