Fluorous-Tethered Amine Bases for Organic and Parallel Synthesis: Scope and Limitations.

Abstract The synthesis of fluorous-tethered amine bases is described. These novel fluorous-tethered reagents promote reactions, remove acidic by-products, and scavenge electrophiles. They are readily separated from the reaction mixture by solid phase extraction on a novel mixed sorbent SPE (SCX/fluorous silica gel) delivering products in high yields and purities.