Cotrimoxazole resistance in Streptococcus pneumoniae isolated from sputum of HIV-positive patients

The prevalence and cotrimoxazole susceptibility of Streptococcus pneumoniae isolated from sputum of 100 HIV-positive patients attending the Nigeria Institute of Medical Research clinic was investigated using standard microbiological methods. Eleven of the sputum specimens grew Streptococcus pneumoniae. Antimicrobial susceptibility test showed that all the isolates were sensitive to amoxicillin, augmentin, erythromycin and chloramphenicol but were resistant to cotrimoxazole. Continuous surveillance of S pneumoniae in sputum samples of HIV-positive subjects in this environment is necessary in order to regulate treatment regimen, considering that cotrimoxazole is the drug recommended by WHO for respiratory infections in HIV patients. Usando metodos microbiologicos convencionales, se investigo la prevalencia y la susceptibilidad al cotrimoxazol, del neumococo Streptococcus pneumoniae aislado a partir del esputo de 100 pacientes VIH-positivos que asistian a la clinica del Instituto Nigeriano de Investigaciones Medicas, Once de las muestras de esputo desarrollaron Streptococcus pnemoniae. La prueba de susceptibilidad antimicrobiana mostro que todos los aislados eran sensibles a la amoxicilina, la augmentina, la eritromicina, y el cloranfenicol, pero resistentes al cotrimoxazol. La vigilancia continua de S pneumoniae en las muestras de esputo de sujetos VIH positivos en este ambiente, es necesaria para regular el regimen del tratamiento, tomando en consideracion que el cotrimoxazol es el medicamento recomendado por la OMS para las infecciones respiratorias en los pacientes de VIH.