Applications of bruceine D in preparing Wnt/Notch signal channel inhibitor drugs

The invention provides applications of bruceine D in preparing a Wnt/Notch signal channel inhibitor preventing/treating drug. The Wnt/Notch signal channel inhibitor preventing/treating drug is a drug composition which is prepared by taking bruceine D as an active ingredient, and is prepared from bruceine D and a pharmaceutic adjuvant, and can be prepared into oral preparations, injection preparations, or transdermal drugs. A human liver cancer tumor cell line model and a human normal liver cell line model are used for evaluating in vitro antitumor effect of bruceine D, a zebra fish model is used for evaluating inhibition effect of bruceine D on Wnt/Notch signal channel, and it is confirmed by experiment results that body axis dysplasia caused by inhibition of Wnt signal channel is observed when death of zebra fish is not caused by 100 M of bruceine D. Influences of bruceine D on Wnt-Notch signal channel key proteins are disclosed by in vitro and vivo antitumor activity experiments of bruceine D for the first time, the important effect of Wnt-Notch signal channel on liver cancer, and the inner relationship of Wnt-Notch signal channel are confirmed, novel applications of bruceine D in preparing the drugs used for preventing/treating liver cancer are provided, the drugs used for preventing/treating liver cancer are provided for clinical therapy, and high application value is achieved.