A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

John G. Menting,Joanna Gajewiak,Christopher A. MacRaild,Danny Hung-Chieh Chou,Maria M. Disotuar,Nicholas A. Smith,Charleen Miller,Judit Erchegyi,Jean Rivier,Baldomero M. Olivera,Briony E. Forbes,Brian J. Smith,Raymond S. Norton,Helena Safavi-Hemami,Michael C. Lawrence

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

2016

John G. Menting
Joanna Gajewiak
Christopher A. MacRaild
Danny Hung-Chieh Chou
Maria M. Disotuar
Nicholas A. Smith
Charleen Miller
Judit Erchegyi
Jean Rivier
Baldomero M. Olivera
Briony E. Forbes
Brian J. Smith
Raymond S. Norton
Helena Safavi-Hemami
Michael C. Lawrence

Structural elucidation and biochemical analysis of a cone snail insulin venom that binds and activates the human insulin receptor may permit design of ultrafast-acting insulin analogs for diabetes therapy.

Keywords:

Conus geographus
Insulin
Cone snail
Hormone
Venom
Biochemistry
Insulin receptor binding
Insulin receptor
Biology
Endocrinology
Internal medicine
Ligand (biochemistry)
human insulin
Receptor

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