PD31 - Pseudoallergic reactions to food and drugs in children with chronic idiopathic urticaria

Chronic idiopathic urticaria (CIU) is a condition in which histamine is constantly released from activated mastocytes and basophiles. A low degranulation threshold of mastocytes in response to different stimuli is described. Diamin oxidase defficiency can be found in patients with CIU. In children with CIU foods and drugs that interact with histamine metabolism can cause pseudoallergic reactions. For children few data in this field are available. Pseudoallergic reaction tends to appear at 4-6 hours after the ingestion of the culprit substance and are usualy not life-threatening.