Bone cartilage transplants fabricated by TPA based on biocompatible polymers

Industrial High Precision 3D Lithography via Two-Photon Absorption (TPA) is a potential disruptive tool for microfabrication that enables novel products for diverse applications in the field of optics, photonics, biomedicine, and life sciences. A customized therapeutic approach to develop bone cartilage transplants for patients with arthrosis by means of TPA is presented. These implants consist of scaffolds as extracellular matrices (ECM) that mimic natural tissue and serve as physical and bioactive support for the generation of autologous tissue capable of replacing or repairing damaged tissue. The variable TPA technology with adjustable precision and structure dimension is the key to a defined micro structuring that enables hierarchically 3D micro structured monolithic biphasic scaffolds for the therapy of bone cartilage damage on an industrial scale.