c-fos Immunoreactivity at the Auditory and Visual Cortex in Experimentally Induced Deafness in Guinea Pigs

Background and Objectives：Recently, functional studies for auditory cortex are being watched with interest in acordance with development of many radiologic equipments and surgical devices for sensorineural hearing los. Moreover, it is wel known that the function of central auditory pathway is esential for hearing rehabilitation. There are some papers that reported about the y was to investigate indirectly the metabolic changes of primary auditory cortex and visual cortex in the c-fos imunoreactivity in an experimentally induced permanent threshold shift animal model. Materials and Method：Ototoxic drugs (kanamycin and furosemide) and noise were used for the induction of permanent threshold shift. Cochlear damages were evaluated with auditory brainstem responses (ABR) and morphologic studies. The c-fos immunoreactivity was observed with a lapse of time after deaf-ening. Results：Conclusion：of auditory-visual cross modal plasticity. (Korean J Otorhinolaryngol-Head Neck Surg 2008 ;51 :602-8)