Preparation process of moxifloxacin hydrochloride sodium chloride injection

2016 
The invention aims at providing a preparation process of a moxifloxacin sodium chloride injection with better quality, good stability and small side effect. The preparation method of the moxifloxacin hydrochloride injection provided by the invention comprises the following steps: step 1, weighing: respectively weighing moxifloxacin hydrochloride and sodium chloride by formula dosage and preparing for later use; step 2: preparing a solution (1): taking water for injection, adding moxifloxacin hydrochloride, stirring until full dissolution, adding medicinal carbon, homogenizing, stirring for absorption, removing carbon and filtering by a filter membrane, washing the carbon layer with a proper amount of water for injection and reserving the filtrate for later use; step 3: preparing a solution (2): taking water for injection, adding full dose of sodium chloride by formula dosage, stirring until full dissolution, cooling, adding medicinal carbon, homogenizing, stirring for absorption, removing carbon and filtering by a filter membrane, then washing the carbon layer with water for injection, combining the filtrates, adding water for injection to full dose, regulating the pH value and homogenizing for later filling; and step 4: filling: filtering by a microporous filter membrane for liquid medicine, filling the filtrate into glass infusion bottles, charging nitrogen, plugging and capping for later sterilization.
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