Preventing PICS with the ABCDEF Bundle

Post-intensive care syndrome (PICS) is a complex constellation of cognitive, physical, and psychological impairments that impact survivors of critical illness, leading to disability, frailty, and poor quality of life. Numerous interventions have been studied to reduce the impact of the syndrome. A coordinated and synergistic bundle of care, called the ABCDEF bundle, has been shown to improve mortality and reduce many of the complications of critical illness including ICU readmissions and discharges to nursing homes and rehabilitation facilities. The bundle combines evidence-based and refined processes of care in sedation and analgesia management, weaning protocols from mechanical ventilation, delirium prevention and treatment, early mobilization, and family engagement to improve outcomes and reduce the burden of PICS amongst ICU survivors.