Preclinical analysis of an autologous CD4-targeted chimeric antigen receptor T-cell (CAR-T) immunotherapy for relapsed or refractory peripheral T-cell lymphoma (PTCL) or cutaneous T-cell lymphoma (CTCL).

Eric Zeng,Tailan Zhan,Yang Wu,Meili Chen,Junzheng Wang,Zhang Yun,Tu Xiaojie,Shuai Yang,Wang Zhang,Tonia Nesheiwat,Frank Liang,Raghu Tadagavadi,Kathy Chai,Dong Geng,Shu Wu

Preclinical analysis of an autologous CD4-targeted chimeric antigen receptor T-cell (CAR-T) immunotherapy for relapsed or refractory peripheral T-cell lymphoma (PTCL) or cutaneous T-cell lymphoma (CTCL).

2021

Eric Zeng
Tailan Zhan
Yang Wu
Meili Chen
Junzheng Wang
Zhang Yun
Tu Xiaojie
Shuai Yang
Wang Zhang
Tonia Nesheiwat
Frank Liang
Raghu Tadagavadi
Kathy Chai
Dong Geng
Shu Wu

e14510Background: CD4 is highly and uniformly expressed T-cell lymphomas (TCL) including PTCL and CTCL, suggesting its potential as a surface target for CAR-T therapy. However, there is a significa...

Keywords:

Medicine
Chimeric antigen receptor
car t cells
Cancer research
Refractory Peripheral T-cell Lymphoma
Cutaneous T-cell lymphoma
Immunotherapy
T cell

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