Функциональный статус нейтрофилов у пациентов с хроническими рецидивирующими инфекциями различной этиологии

Objective: complex assessment of the functional status of neutrophils in patients with chronic recurrent furunculosis (CRF) and recurrent herpetic infection (RHI). Material and methods. We have studied the functional status of neutrophils: ROS-, NO-production and NET-generation, apoptosis, phagocytosis, and bactericidal ability of 103 patients with CRF and 238 patients with RHI examined during remission and exacerbation stages. Conclusion. The patients examined during remission showed the same type of the functional status changes of neutrophils in comparison with healthy individuals. The exception was the parameters of the bactericidal activity of neutrophils decreased in the patients with CRF. During the acute stage we marked the maximum changes of netosis and apoptosis. We have defined the possibility of using these data for more precise differentiation of exacerbation and remission in patients with CRF and RHI.