Pyridone derivatives-2-one as modulators system stress activated protein kinase

A compound having the structure Ia Gender: ** ** Formula Ia Gender; wherein R2 is CO-glucorunida, R1, R3, and R4 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 substituted alkyl, alkenyl C1-C10, C1-C10 nitroalkyl C1-C10 , C1-C10 thioalkyl, C1-C10 hydroxyalkyl, C3-C10 alkoxy, phenyl, substituted phenyl, halogen, hydroxyl, C1-C10 alkoxyalkyl, C1-C10 carboxy, C1-C10, CO-uronida, CO-monosaccharide, CO- CO-oligosaccharide and polysaccharide; and X1, X2, X3, X4 and X5 are independently selected from the group consisting of H, halogen, C1-C10 alkoxy and hydroxy.