Roles of potassium channel in effects of resveratrol on isolated myocardial contractility and heart rate research in guinea pig

Objective: To study the effects of resvaratrol derivatives on spontaneous HR and CF of isolated guinea pig atrium.Method: The dose-effect curve of resvaratrol was observed.The possible mechanism of potassium channels responsible for changes of CF and HR after administering with resvaratrol was measured.Result: Resvaratrol reduced the spontaneous HR and weakened the CF in a dose-dependent manner ranging from 10-6 to 3×10-4mol·L-1(P0.05).As compared with Res group,the effects were partly blocked by Gli(P0.05) and TEA(P0.01),but not blocked by 4-AP,BaCl2,Atropine.Conclusion: Resvaratrol can induce negative chronotropic action and negative inotropic action.The mechanism(s) may relate to the opening of KATP and KCa.