An Efficient Synthesis of Pyrrole and Fluorescent Isoquinoline Derivatives Using NaN3/NH4Cl Promoted Intramolecular Aza‐Annulation.

Abstract An efficient synthetic protocol of pyrroles and isoquinolines through NaN3/NH4Cl promoted intramolecular aza-annulation of formyl group with suitable alkenes or alkynes is described in high yield and regioselectivities. The metal free exo-trig and endo-dig aza-cyclisation has been extended for the synthesis of bicyclic or tricyclic pyrroles along with environment sensitive fluorescent isoquinoline derivatives. Reactions occur in excellent yields, broad scope and high tolerance of functional groups. The synthetic utility of this methodology was demonstrated in the short synthesis of the core structure of lamellarin Q.