Retro-biosynthetic construction of corynanthe alkaloid skeletons from rhynchophylline alkaloids
2019
Rhynchophylline alkaloids are bio-synthesized from corynanthe alkaloids via an oxidative rearrangement. We demonstrate here that corynanthe alkaloids could be generated from rhynchophylline alkaloids in a retro-biosynthetic manner via a Wagner–Meerwein rearrangement. A series of corynanthe analogues were afforded with good functional group tolerance and satisfactory yields.
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