Preparation of Usolic Acid Solid Dispersion Capsule and Study on its Dissolution in vitro

Objective To evaluate the dissolution in vitro and quality of three kinds of preparations.Methods Using PVP-K30 as water soluble carrier,ursolic acid solid dispersion capsule was prepared by a solvent method.The HPLC method for determination of the dissolution in vitro of ursolic acid preparations was established.The existed form of ursolic acid in preparations was detec- ted.Results HPLC method was accurate and reliable,and no interference occurred from carriers.The dissolution rate in vitro of ursolic acid solid dispersion capsule increased 2.3 and 1.1 times than tablet and mixture capsule within 45 min,respectively. Conclusion The solid dispersion capsule with PVP-K30 remarkably improves the dissolution rate of ursolic acid.