Synthesis of RWJ 68354: A Potent Inhibitor of the MAP Kinase p38.

James R. Henry,John H. Dodd

Synthesis of RWJ 68354: A Potent Inhibitor of the MAP Kinase p38.

1999

James R. Henry
John H. Dodd

Abstract The regiospecific synthesis of RWJ 68354, a potent inhibitor of the p38 MAP kinase, via a variation of the Bischler-Mo¨hlau indole synthesis is reported.

Keywords:

Stereochemistry
p38 mitogen-activated protein kinases
Mitogen-activated protein kinase
Chemistry
Organic chemistry

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