Regio- and Enantioselective Iridium-Catalyzed Allylation of Thiophenol: Synthesis of Enantiopure Allyl Phenyl Sulfides

Shengcai Zheng,Ning Gao,Wei Liu,Dongge Liu,Xiaoming Zhao,Theodore Cohen

Regio- and Enantioselective Iridium-Catalyzed Allylation of Thiophenol: Synthesis of Enantiopure Allyl Phenyl Sulfides

2010

Shengcai Zheng
Ning Gao
Wei Liu
Dongge Liu
Xiaoming Zhao
Theodore Cohen

A highly regio- and enantioselective allylic alkylation of sodium thiophenoxide has been realized by [Ir(COD)Cl]2/phosphoramidite along with CsF as an additive, producing highly enantioenriched allyl phenyl sulfide compounds with up to 99% ee.

Keywords:

Sodium
Tsuji–Trost reaction
Enantioselective synthesis
Photochemistry
Catalysis
Thiophenol
Iridium
Organic chemistry
Sulfide
Chemistry
Phosphoramidite
Allylic rearrangement
Enantiopure drug

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