Halogenated imidazolidin-2,4-dione and its utlilización as cancer drug

2010 
Compound of general formula (I) in racemic, enantiomeric form or any combination of these forms and in which R1 and R2 independently represent a halogen atom or an alkyl, haloalkyl, alkoxy, cyano, nitro, amino, alkylamino dialkylamino, -NR8-CO-R5, -NR 8 SO 2 R 5, -NR 8 CO- (CH2) n-NR6R7, -NR8-SO2- (CH2) n -CO-NH2 NR6R7o; n represents an integer chosen from 0, 1, 2, 3, 4, 5 and 6; R5 represents an alkyl, aryl or heteroaryl; R6 and R7 independently represent a hydrogen atom, an alkyl radical or an alkyloxycarbonyl; R8 represents a hydrogen atom or an alkyl radical; R3 represents an alkyl radical or a hydrogen atom; or the two radicals R 3 form together with the atom to which decarbono are attached, a cycloalkyl radical comprising 3 to 6 members; R4 represents a haloalkyl radical of 2 to 10 carbon atoms; Y represents an alkylene chain of 2 to 14 carbon atoms, straight or branched, it being possible for this cadenasaturada or unsaturated, and may contain one or more additional members -O-; X represents -S-, -SO-, -SO2-, -S> = N (R9) - or -S (O)> = N (R9) -; R9 represents a hydrogen atom or haloalkylcarbonyl radical, or a salt pharmaceutically acceptable latter.
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