Formulation and evaluation of Pioglitazone loaded Bovine serum albumin nanoparticles along with Piperine

Abstract Aim To formulate and optimize the process parameters of Pioglitazone and Piperine loaded BSA nanoparticles. This will serve the purpose avoiding the adverse effects of Pioglitazone by combining with herbal principle, Piperine. Methods Modified desolvation and coacervation method was selected for the formulation of nanoparticles. Method of cross linking, concentration of glutaraldehyde and pH were optimized. Results BSA nanoparticles loaded with Pioglitazone and Piperine were prepared. The loading efficiency was found to be maximum (81.5 ± 1.7) with chemical cross linking at 10% of glutaraldehyde and in alkaline pH. The size of the nanoparticles was in nano range and minimum with cocervation at alkaline pH. The drug release was found to be sustained upto 24 h and was efficient with nanoparticles formed at alkaline pH due to more surface area for dissolution. Conclusion The formed BSA nanoparticles loaded with Piperine and Pioglitazone will be beneficial for the treatment of diabetes.