Induction of the Mucosal Immune Response

Exposure to antigens via mucosal membranes is well known to induce responses in the common mucosal system dominated by secretory IgA (SIgA), whereas parenterally given antigens are generally not considered to induce SIgA antibody production. Recent studies on the effect of vaccination suggests, however, that the antibody response patterns may be rather more complex, with many exceptions from the above concept (Mestecky 1987). Thus, parenteral vaccination can lead to a mucosal response, while intestinal exposure may result in predominantly serum responsiveness. This brief review will bring out some recent studies illustrating the wide range of conditions influencing the mucosal antibody response.