Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin

Nadira Friesen,Amanda S. Büchau,Patricia Schott-Ohly,Abdelhakim Lgssiar,Helga Gleichmann

Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin

2004

Nadira Friesen
Amanda S. Büchau
Patricia Schott-Ohly
Abdelhakim Lgssiar
Helga Gleichmann

Aims/hypothesis We studied the impact of the reactive oxygen species hydrogen peroxide (H2O2) and antioxidative enzymes on the pathogenesis of diabetes induced by multiple low doses of streptozotocin (MLD-STZ).

Keywords:

Catalase
Superoxide dismutase
Hydrogen peroxide
Glutathione peroxidase
Pancreatic islets
Endocrinology
Internal medicine
Diabetes mellitus
Streptozotocin
Reactive oxygen species
Biology
Enzyme
Pathogenesis
Ratón

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