Pharmacokinetics and Tissue Distribution of Apigenin Niosomes

OBJECTIVE To study the preparation of apigenin niosomes and their pharmacokinetics in rats and tissue distribution in mice.METHODS Apigenin niosomes was prepared by ethanol injection method.The pharmacokinetics and tissue distribution of apigenin niosomes and apigenin solution were carried out in Wistar rats and KM mice by caudal vein injection, respectively.RESULTS The entrapment efficiency of the niosomes was(69.48±2.5)% , the average particle size was(148±5.03)nm.Compared with apigenin injection,the circulation time of apigenin niosomes in plasma was longer.The t1/2 was increased by 2.02 fold ,the AUC0-∞ was increased by 1.85 fold and MRT0-∞ was increased by 2.16 fold.The AUCs-∞ of liver,lung and brain were much bigger,while less in heart and kidney.CONCLUSION Apigenin niosomes can prolong the circulation in vivo,and reduce the accumulation in heart and kidney,which can improve curative effects and reduce toxicity.