The mechanism of the local inflammatory reaction induced by compound 48/80 and dextran in rats.

The butanolamide of 1-methyl-lysergic acid (UML) and cyproheptadine are strong inhibitors of the local inflammatory reaction induced by 5-hydroxytryptamine (5-HT) in rats, but only cyproheptadine is active against histamine. As cyproheptadine is more active than UML in reducing the local oedema reaction induced by dextran and compound 48/80 in intact and adrenalectomised rats, it is suggested that both histamine and 5-HT are involved in the reaction