TAP deficiency is also a cause of bronchiectasis.

We read with interest the recent bronchiectasis review by Whitters and Stockley.1 The authors provide a comprehensive overview of the changes in the immune response that might favour bacterial colonisation of the lower airways and in a second step initiate the vicious cycle leading to chronic inflammation and recurrent infections. Their description of the innate immune system in the lung includes antibacterial peptides, neutrophils and toll-like receptors. Although this is correct, Natural Killer (NK) cells might also be mentioned, as their role in the immune response to bacteria (besides their antiviral and antitumor …