PROGNOSTIC SIGNIFICANCE OF ŒSTROGEN UPTAKE BY HUMAN BREAST-CANCER TISSUE

Abstract The uptake of radio-labelled œstradiol by human breast-tumour tissue in vivo has been studied in relation to the response of the patient to endocrine therapy. Patients with a low uptake of œstradiol tended not to respond favourably to endocrine ablation or to androgen therapy. The converse was not true; high œstradiol uptake was found in several patients who did not respond to treatment.