An preliminarily experimental study of bone mineral density mediated by new tuberculosis-controlled release composite

Objective To investigate bone mineral density （BMD） after filling in the bone scaffolds with anti-tuberculosis controlled-release microspheres, and provide experimental basis for decrease of the side effects of anti-tuberculosis therapy after spinal surgery. Methods The bone densitometer was used to observe the changes of bone mineral density before and after the infusion with the artificial allograft bone （ Group A）, the controlled release complex of the RFP Controlled-release microspheres-artificial allograft bone （ Group B）, and RFP-artificial allograft bone complex （ Group C）, respectively. Results BMDs of three groups before perfusion were not different significantly [Group A：（0. 191 ＋0. 018）g/cm2 ; Group B：（0. 186 ±0. 016）g/cm2; Group C： （0. 189±0. 018）g/ cm2; P 〉 0. 05 ]. BMDs of three groups after perfusion were not different significantly [ Group A：（0. 191 ± 0. 018）g/cm2 ; Group B： （0. 179 ±0. 023）g/cm2; Group C：（0. 185 ±0. 021）g/era2; P 〉0. 05]. Conclusions RFP mierospheres using ultrasonic vibration method and the porous bone were prepared to controlled-release anti-tuberculosis complex. BMD of three groups after perfusion were not influenced obviously. Key words: Antitubercular agents;  Delayed-action preparations;  Mierospheres;  Bone density