The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick

Abstract The clonal proliferation of chicken granulocytic progenitors was inhibited 5–20-fold by the eiconsanoid, 5-HETE, at 1.0 μM. Inhibition occurred at the lowest concentration measured (0.12μM). This compound at 0.6 to 1.0 μM also inhibited the clonal proliferation of chick embryo fibroblasts by as much as 10-fold.