[Two single nucleotide polymorphisms of beta 2-adrenoceptor gene in elderly patients with hypertension].

Objective To investigate the association of two single nucleotide polymorphisms (SNPs) of β 2-adrenoceptor (β 2-AR) gene with hypertension in elderly patients.Methods The study samples were collected from unrelated Chinese Han population of Dabie Mountain in Anhui province. Eighty-six elderly patients with hypertension and 43 controls were selected. Genotypes of +1053 and +1239 SNPs were typed by polymerase chain reaction-restriction fragment length polymorphism.Results The frequencies of the two SNPs complied well with the Hardy-Weinberg equilibrium in normal group. The distribution of genotypes AA, GA,GG of the SNP at locus+1239 in moderate and severe hypertension group was significantly different from that in normal group (χ 2=8.67, P 0.05). There were evident differences in the frequencies of alleles of the two groups (χ 2=4.02, P 0.05). No significant difference was observed in the distribution of genotypes of the SNP at locus+1053 between the two groups.Conclusion These data indicate that the SNP at locus+1239 of β 2-AR gene is associated with hypertension in elderly patients.