Fabrication of Ag–ZnO@ carboxymethyl cellulose/K-carrageenan/graphene oxide/konjac glucomannan hydrogel for effective wound dressing in nursing care for diabetic foot ulcers

2019 
In the present investigation, a new Ag–ZnO loaded carboxymethyl cellulose/K-carrageenan/graphene oxide/konjac glucomannan (Ag–ZnO@CGK) hydrogel was effectively prepared by means of a straight forward two step technique for clinical applications as wound-recuperating materials. In the first step, silver nanoparticles were synthesized with green deoxidizer mango peel extracts. The Ag–ZnO@CGK hydrogel indicated incredible swelling assimilation and impressive mechanical properties. Also, Ag–ZnO@CGK hydrogel exhibited great bactericidal movement against test microorganisms. In vitro viability testing demonstrated that fibroblast cells could endure well within the sight of Ag@CGK hydrogel, showing that Ag–ZnO@CGK hydrogel has great viability. In vivo animal models demonstrated that the Ag–ZnO@CGK hydrogel adequately quickened wound recuperating and histological examinations demonstrated that they have advanced fibroblast development and quickened epithelialization. The test results demonstrated that Ag–ZnO@CGK hydrogel has incredible potential in advanced wound healing.
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