A synthetic lethal approach for compound and target identification in Staphylococcus aureus

Lincoln Pasquina,John P. Santa Maria,B. McKay Wood,Samir H. Moussa,Leigh M. Matano,Marina Santiago,Sara E. S. Martin,Wonsik Lee,Timothy C. Meredith,Suzanne Walker

A synthetic lethal approach for compound and target identification in Staphylococcus aureus

2016

Lincoln Pasquina
John P. Santa Maria
B. McKay Wood
Samir H. Moussa
Leigh M. Matano
Marina Santiago
Sara E. S. Martin
Wonsik Lee
Timothy C. Meredith
Suzanne Walker

A series of synthetic lethal strategies identifies a small-molecule inhibitor of Staphylococcus aureus DltB, links teichoic acid D-alanylation to virulence and identifies synergistic antibiotic drug combinations.

Keywords:

Drug
Teichoic acid
Biology
Antibiotics
Staphylococcus aureus
Virulence
Bacteria
Microbiology
Bacterial Processes
Druggability
Biochemistry
Membrane transport protein
Chemical genetics

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