Statistical Methods for Quality of Life Studies. Design Measurements and Analysis.

Acknowledgements. Preface. Presenting Authors. Introduction D.R. Cox. 1: Measurement, Scale Development, and Study Design. regulatory Aspects of Quality of Life C. Gnecco, P.A. Lachenbruch. Biases in the Retrospective Calculation of Reliability and Responsiveness from Longitudinal Studies G. Norma, et al. Application of the Multi-attribute Utility Theory to the Development of a Preference based Health-Related Quality of Life Instrument C. Le Gales. Strategy and Methodology for Choice of Items in Psychometric Measurement: Designing a Quality of Life Instrument for Hip and Knee Osteoarthritis F. Guillemin, et al. Conception, Development and Validation of Instruments for Quality of Life Assessment: An Overview A.J. Chwalow, A.B. Adesina. Methodological Issues in the Analysis of Quality of Life Data in Clinical Trials: Illustrations from the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trial S. Land, et al. Disease-Specific Versus Generic Measurement of Health-Related Quality of Life in Cross-Sectional and Longitudinal Studies: an Inpatient Investigation of the SF-36 and Four Disease-Specific Instruments S. Briancon, et al. 2: Analysis and Interpretation of Multiple Endpoints. Analyzing Longitudinal Health-Related Quality of Life Data: Missing Data and Imputation Methods D.A. Revicki. Comparison of Treatments with Multiple Outcomes P. Tubert-Bitter, et al. The Use of Soft Endpoints in Clinical Trials: The Search for Clinical Significance J. Wittes. 3: Item Response Theory and Rasch Models. Parametric and Nonparametric Item Response Theory Models in Health Related Quality of Life Measurement I.W. Molenaar. Questionnaire Reliability Under the Rasch Model A. Hamon, M. Mesbah. Item Response Theory (IRT): Applications in Quality of LifeMeasurement, Analysis and Interpretation D. Cella, et al. Graphical Rasch Models S. Kreiner, K.B. Christensen. 4: Joint Analysis of Quality of Life and Survival. Semi-Markov Models for Quality of Life Data with Censoring N. Heutte, C. Huber-Carol. A Model Relating Quality of Life of Latent Health Status and Survival M.-L. Ting Lee, G.A. Whitmore. Applying Survival Data Methodology to Analyze Longitudinal Quality of Life Data L. Awad, et al. Latent Class Models to Describe Changes Over Time: A Case Study H.C. van Houwelingen. 5: Quality-Adjusted Survival Analysis and Related Methods. Prevalence Analysis of Recurrent and Transient Health States in Quality of Life Studies A. Kramar, R. Lancar. Measures of Quality Adjusted Life and Quality of Life Deficiency: Statistical Perspectives P.K. Sen. Quality-Adjusted Survival Analysis in Cancer Clinical Trials B.F. Cole, K.L. Kilbridge. 6: Methods for Informatively Missing Longitudinal Quality-of-Life Data. Handling of Missing Data M. Chavance. Guidelines For Administration of Self-Reported Health-Related Quality of Questionnaires: How to Minimize Avoidable Missing Data? D. Dubois. Joint Analysis of Survival and Nonignorable Missing Longitudinal Quality-of-Life Data J.-F. Dupuy. Multiple Imputation for Non-Random Missing Data in Longitudinal Studies of Health-Related Quality of Life D.L. Fairclough. Strategies to Fit Pattern-Mixture Models G. Molenberghs, et al. Analysis of Longitudinal Quality of Life Data with Informative Dropout M.C. Wu, et al.