Nomogram for Estimating Plasma Unbound Disopyramide Concentrations in Patients with Varying Plasma α1-Acid Glycoprotein Concentrations

SummarySince plasma protein binding of disopyramide (DP)—a class IA antiarrhythmic widely used in the prevention and treatment of various types of cardiac arrhythmias—is not only saturable within the therapeutic range but also altered under various pathophysiological conditions, the interpretation o