Gamete/Embryo-Fetal Origins of Tumours
2014
Epidemiological and animal studies indicate that carcinogenesis may start as early as the prenatal period. Modifying the prenatal environment may alter genes through the epigenetic route, and, these alterations may be inherited by the offspring. Epigenetic factors like nutritional factors, endocrine disruptors, infection and lifestyle may affect tumour development, or, target cell differentiation to increase susceptibility to cancer. In this chapter, we discuss the evidence related to embryo-fetal origins of tumours.
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