Experimental study on neuron apoptosis of the cerebral injury induced by hypoxia-hypercapnia in rats.

Objective To explore the morphological change of the cerebral injury induced by hypoxia-hypercapnia. Method A rat's model induced by hypoxia-hypercapnia was established. The morphological changes of the cerebral injury were observed by using electron microscopy, TUNEL staining and flow cy-tometry. Results Degeneration, necrosis and apoptosis of neural cell were observed in the cerebral cortex and hippocampus in the injured rats. Conclusion The changes mentioned above might be useful for the forensic pathological diagnosis of the cerebral injury induced by hypoxia-hypercapnia.