Análise imunoistoquímica comparativa da periimplantite com a periodontite em humanos

As proteses implanto-suportadas sao largamentes aceitas como uma opcao de tratamento confiavel e previsivel para a reabilitacao de pacientes completamente ou parcialmente desdentados. Espera-se, entretanto, que o numero de pacientes sofrendo de alguma alteracao dos tecidos periimplantares aumente em funcao do tempo de uso dos implantes osseointegraveis. Nesse estudo foram comparados microscopicamente e imunoistoquimicamente 10 casos de periodontite com 10 casos de periimplantite em humanos originados dos arquivos do Departamento de Estomatologia, Disciplina de Patologia da Faculdade de Odontologia de Bauru - USP compreendendo o periodo de 1963 a 2004. Foram escolhidos marcadores imunoistoquimicos para as seguintes celulas: NK (CD56), Pan-T (PS1), Macrofagos (KP1), Linfocitos T4 (CD4), Linfocitos T8 (CD8), Pan-B (L26); e moleculas: EGFR, E-Caderine, IgG, IgM e IgA. Analise estatistica t Student (P Actually, implant-supported prostheses are widely accepted as a reliable treatment modality, but failures in longitudinal studies have been shown. In some cases, periimplantites with a progressive periodontal bone loss takes place, and mechanical or load factors and biological or plaque-induced lesions have been claimed as main etiologic factors. We compared ten cases of periimplantitis, with ten cases of periodontitis in order to give new findings on the peri-implant tissue breakdown. Specimens from the peri-implant and periodontal tissue were taken in ali cases for histological and immunohistochemical analysis, including the analysis of NK (C056), Pan-T (PS1), Macrophage (KP1), Lymphocyte T4 (C04), Lymphocyte T8 (C08), Pan-B (L26), EGFR, E-Caderine, IgG, IgM e IgA. It was demonstrated that both lesions harbored large inflammatory cell infiltrates. Statistics analysis demonstrated that the proportions of the various parameters studied were similar (P