Method of screening for pharmaceutical candidate substances

Using chimeric mice transplanted with human hepatocytes, a method for screening a drug-metabolizing enzyme CYP2D6, CYP2C9, drug candidate to be primarily metabolized by CYP2C19, pharmaceutical candidate substance, CYP2D6, CYP2C9 or CYP2C19 deficient Guide, It provides methods for determining whether or not metabolized. Furthermore, using human liver transplantation chimeric mice, the pharmaceutical candidate substance drug-metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, or for any of CYP3A4 to provide a method for determining whether to induce or inhibit the activity.