Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency
2019
GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii . This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.
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