Bleomycin Induces Drug Efflux in Lungs: A pitfall for Pharmacological Studies of Pulmonary Fibrosis

Joshua K. Park,Nathan J. Coffey,Steven P. Bodine,Charles N. Zawatsky,Lindsey Jay,William A. Gahl,George Kunos,Bernadette R. Gochuico,May Christine V. Malicdan,Resat Cinar

Bleomycin Induces Drug Efflux in Lungs: A pitfall for Pharmacological Studies of Pulmonary Fibrosis

2019

Joshua K. Park
Nathan J. Coffey
Steven P. Bodine
Charles N. Zawatsky
Lindsey Jay
William A. Gahl
George Kunos
Bernadette R. Gochuico
May Christine V. Malicdan
Resat Cinar

Rationale: ATP-binding cassette (ABC) transporters are evolutionarily conserved membrane proteins that pump a variety of endogenous substrates across cell membranes. Certain subfamilies are known t...

Keywords:

Efflux
Pulmonary fibrosis
Idiopathic pulmonary fibrosis
Bleomycin
Drug resistance
Biology
Cell
Endogeny
Biochemistry
Pharmacology
Membrane protein

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