Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Julia Joung,Jesse M. Engreitz,Silvana Konermann,Omar O Abudayyeh,Vanessa Verdine,François Aguet,Jonathan S. Gootenberg,Neville E. Sanjana,Jason Wright,Charles P. Fulco,Yuen-Yi Tseng,Charles H. Yoon,Jesse S. Boehm,Eric S. Lander,Feng Zhang

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

2017

Julia Joung
Jesse M. Engreitz
Silvana Konermann
Omar O Abudayyeh
Vanessa Verdine
François Aguet
Jonathan S. Gootenberg
Neville E. Sanjana
Jason Wright
Charles P. Fulco
Yuen-Yi Tseng
Charles H. Yoon
Jesse S. Boehm
Eric S. Lander
Feng Zhang

Long noncoding RNAs are investigated using a CRISPR–Cas9 activation screen and shown to confer BRAF inhibitor resistance on melanoma cells through various local mechanisms.

Keywords:

Neighbourhood (mathematics)
Melanoma
Locus (genetics)
BRAF inhibitor
Genome
Gene
Genetics
Biology
CRISPR
Human genome
Phenotype
Regulation of gene expression
RNA

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